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Superoxide in cigarette smoke is transported through the bloodstream to the vascular endothelium, where it reacts with nitric oxide to form peroxynitrite anion (ONOO), which is severely cytotoxic (29)

Given that tobacco use has not been found to be a risk factor for neurocognitive impairment in PLWH [29], it is important to determine the impact of smoking on cognitive control in PLWH, particularly on target detection

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